Research Press Release

August 7, 2019


Our project is featured in the Research News of Hokkaido University!


We have succeeded in reducing proviral levels of bovine leukemia virus in cattle with severe infections by the combined treatment of an immune checkpoint inhibitor (an anti-PD-L1 antibody) and a COX-2 inhibitor. The finding could be utilized to control chrionic infections in cattle.


For more details, see the following link:

The drug combination effective against bovine leukemia


This release is related to the original article below:

Sajiki Y et al., Prostaglandin E2-Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti-PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection. J. Immunol., in press. DOI: 10.4049/jimmunol.1900342 (open access)



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