Research Highlight
July 25, 2025
Our recent publication was introduced in the Science Japan, an online magazine offering a comprehensive overview of breaking science & technology news from Japan.
It was launched in 2021 by the Japan Science and Technology Agency (JST), one of Japan's largest national research funding agencies.
Please click the link below!
▶Science Japan
Anti-CTLA-4 antibody treatment effective for canine cancer
https://sj.jst.go.jp/news/202507/n0717-01k.html
In this study, we demonstrated that combination therapy with anti-CTLA-4 antibody may be effective even in dogs that have developed resistance to anti-PD-L1 antibody therapy.
The results were published in the journal Frontiers in Immunology on May 20.
Figure. Antitumor effect of combination therapy in a dog with oral malignant melanoma.
This article is related to the original publication below:
Title:
Journal:
https://doi.org/10.3389/fimmu.2025.1570717 (open access)
Please check our previous press release if you are interested in the history of our study.
Combination therapy effective against canine melanoma (Research Press Release, June 23, 2023)
New therapy target for malignant melanomas in dogs (Research Press Release, April 22, 2021)
New therapeutic antibody for dog cancers (Research Press Release, August 25, 2017)
Research Press Releases
June 23, 2023
Combination therapy effective against canine melanoma
December 22, 2022
Predicting the onset of bovine lymphoma ― Development of cancer screening technology
April 22, 2021
New therapy target for malignant melanomas in dogs
April 2, 2021
Probiotics keep calves healthy, too!
January 29, 2021
Deeper insight into how tick spit suppresses cattle immunity
August 2, 2019
The drug combination effective against bovine leukemia
April 2, 2018
Unraveling the immunopathogenesis of Johne’s disease
August 25, 2017
New therapeutic antibody for dog cancers
June 7, 2017
Overcoming immune suppression to fight against bovine leukemia